Orthotopic GBM model characterization. (A) Tumor cells were isolated... | Download Scientific Diagram
Frontiers | Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future
Frontiers | Next-Generation in vivo Modeling of Human Cancers
PI3Kinase signaling in glioblastoma | SpringerLink
Development of a novel preclinical glioblastoma mouse model and therapeutic impact of IRE1 inhibition | bioRxiv
Buparlisib is a brain penetrable pan-PI3K inhibitor | Scientific Reports
Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future - Frontiers
PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition | PLOS ONE
A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors. - Abstract - Europe PMC
A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity - ScienceDirect
A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors. - Abstract - Europe PMC
Combined treatment of orthotopic GBMs with BKM120 and PD0325901 results... | Download Scientific Diagram
Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response | bioRxiv
Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis | Cell Death & Disease
Novel Therapeutic Venues for Glioblastoma: Novel Rising Preclinical Treatment Opportunities | IntechOpen
Targeting cellular pathways in glioblastoma multiforme | Signal Transduction and Targeted Therapy
Oncoprotein Inhibitor Rigosertib Loaded in ApoE-Targeted Smart Polymersomes Reveals High Safety and Potency against Human Glioblastoma in Mice | Molecular Pharmaceutics
Frontiers | Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies
PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathway genes are over-expressed in... | Download Scientific Diagram
A) Schematic of procedure for generating orthotopic glioblastoma mouse... | Download Scientific Diagram
PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation - ScienceDirect
IJMS | Free Full-Text | Molecular Mechanisms of Drug Resistance in Glioblastoma | HTML
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases | Nature Medicine
